bosentan will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lessen in fentanyl plasma concentrations, not enough efficacy or, maybe, improvement of the withdrawal syndrome inside a client… Read More